Identification of a dinucleotide signature that discriminates coding from non-coding long RNAs.
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ABSTRACT:
SUBMITTER: Ulveling D
PROVIDER: S-EPMC4158813 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Publications
Identification of a dinucleotide signature that discriminates coding from non-coding long RNAs.
Ulveling Damien D Dinger Marcel E ME Francastel Claire C Hubé Florent F
Frontiers in genetics 20140909
To date, the main criterion by which long ncRNAs (lncRNAs) are discriminated from mRNAs is based on the capacity of the transcripts to encode a protein. However, it becomes important to identify non-ORF-based sequence characteristics that can be used to parse between ncRNAs and mRNAs. In this study, we first established an extremely selective workflow to define a highly refined database of lncRNAs which was used for comparison with mRNAs. Then using this highly selective collection of lncRNAs, w ...[more]
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