Ontology highlight
ABSTRACT:
SUBMITTER: Liu P
PROVIDER: S-EPMC4160404 | biostudies-other | 2014 Oct
REPOSITORIES: biostudies-other
Liu Pingsheng P Skelly Jordan D JD Song Jie J
Acta biomaterialia 20140620 10
Zwitterions are well known for their anti-biofouling properties. Past investigations of zwitterionic materials for biomedical uses have been centered on exploiting their ability to inhibit non-specific adsorption of proteins. Here, we report that zwitterionic motifs, when presented in three dimensions (e.g. in crosslinked hydrogels), could effectively sequester osteogenic bone morphogenetic protein-2 (rhBMP-2). The ionic interactions between rhBMP-2 and the 3-D zwitterionic network enabled dynam ...[more]