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Activity and social behavior in a complex environment in rats neonatally exposed to alcohol.

ABSTRACT: Environmental complexity (EC) is a powerful, stimulating paradigm that engages animals through a variety of sensory and motor pathways. Exposure to EC (30 days) following 12 days of wheel running preserves hippocampal neuroplasticity in male rats neonatally exposed to alcohol during the third-trimester equivalent (binge-like exposure on postnatal days [PD] 4-9). The current experiment investigates the importance of various components of EC (physical activity, exploration, social interaction, novelty) and examines whether neonatal alcohol exposure affects how male rats interact with their environment and other male rats. Male pups were assigned to 1 of 3 neonatal conditions from PD 4-9: suckle control (SC), sham-intubated (SI), or alcohol-exposed (AE, 5.25 g/kg/day). From PD 30-42 animals were housed with 24-h access to a voluntary running wheel. The animals were then placed in EC from PD 42-72 (9 animals/cage, counterbalanced by neonatal condition). During EC, the animals were filmed for five 30-min sessions (PD 42, 48, 56, 64, 68). For the first experiment, the videos were coded for distance traveled in the cage, overall locomotor activity, time spent near other animals, and interaction with toys. For the second experiment, the videos were analyzed for wrestling, mounting, boxing, grooming, sniffing, and crawling over/under. AE animals were found to be less active and exploratory and engaged in fewer mounting behaviors compared to control animals. Results suggest that after exposure to wheel running, AE animals still have deficits in activity and social behaviors while housed in EC compared to control animals with the same experience.

SUBMITTER: Boschen KE

PROVIDER: S-EPMC4163121 | biostudies-other | 2014 Sep

REPOSITORIES: biostudies-other

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Activity and social behavior in a complex environment in rats neonatally exposed to alcohol.

Boschen Karen E KE Hamilton Gillian F GF Delorme James E JE Klintsova Anna Y AY

Alcohol (Fayetteville, N.Y.) 20140725 6

Environmental complexity (EC) is a powerful, stimulating paradigm that engages animals through a variety of sensory and motor pathways. Exposure to EC (30 days) following 12 days of wheel running preserves hippocampal neuroplasticity in male rats neonatally exposed to alcohol during the third-trimester equivalent (binge-like exposure on postnatal days [PD] 4-9). The current experiment investigates the importance of various components of EC (physical activity, exploration, social interaction, nov ...[more]

PMID: 25150044

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Project description:Background and aimsAlcohol demand, a measure of alcohol's reinforcing value, is associated with greater alcohol consumption and alcohol-related problems. Although alcohol demand has primarily been evaluated as a 'trait-like', individual difference measure, recent evidence indicates that demand exhibits meaningful short-term fluctuations. We aimed to determine whether moment-to-moment fluctuations in alcohol demand in individuals' natural drinking environments predicted drinking occurrence, drinking continuation, and drinking quantity.DesignObservational study.SettingIndividuals' natural drinking environments in Columbia, Missouri, USA.ParticipantsEighty-nine young adults (56% female; mean age = 24.8) participated from November 2018 to October 2020. Participants reported 14.5 drinking days [standard deviation (SD = 8.1)] and 4.1 drinks per occasion (SD = 2.5) during ecological momentary assessment (EMA).MeasurementsParticipants completed the alcohol purchase task at baseline. Following this, participants reported on their alcohol demand (breakpoint, Omax , intensity) and drinking behavior during EMA at daily, timed prompts from 6 p.m. to 2 a.m. They provided breathalyzer samples using a BACtrack Mobile® Pro. Models tested concurrent and prospective (lagged) associations between alcohol demand and drinking occurrence and drinking continuation after drinking initiation. Additional models tested concurrent associations between demand and breath alcohol concentrations (BrACs).FindingsHigher alcohol demand was associated with higher odds of drinking and continued drinking for all demand indices at the momentary [odds ratio (OR) = 1.27-1.56, ps ≤ 0.03] and day-level (OR = 2.14-3.39, ps < 0.001). Additionally, lagged demand predicted higher odds of drinking occurrence and continuation at the following prompt (OR = 1.32-1.53, ps ≤ 0.004). Higher alcohol demand was associated with higher BrACs at the momentary (bs = 0.0011-0.0026, ps ≤ 0.03) and day-level (bs = 0.0053-0.0062, ps < 0.001). At the person-level, findings varied depending on the demand measure.ConclusionsAlcohol demand appears to be associated with both when and how much individuals drink in their natural drinking environments. Elevations in alcohol demand appear to be associated with increased likelihood of drinking and continuing to drink, and greater total alcohol consumption, both within and across drinking days.

Dataset Information

Activity and social behavior in a complex environment in rats neonatally exposed to alcohol.

Publications

Activity and social behavior in a complex environment in rats neonatally exposed to alcohol.

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