Ontology highlight
ABSTRACT:
SUBMITTER: Hernando N
PROVIDER: S-EPMC41647 | biostudies-other | 1995 Jun
REPOSITORIES: biostudies-other
Hernando N N Bartkiewicz M M Collin-Osdoby P P Osdoby P P Baron R R
Proceedings of the National Academy of Sciences of the United States of America 19950601 13
We have identified a second isoform of the catalytic A subunit of the vacuolar H+ pump in chicken osteoclasts. In this isoform (A2) a 72-bp cassette replaces a 90-bp cassette present in the classical A1 isoform. The A1-specific cassette encodes a region of the protein that contains one of the three ATP-binding consensus sequences (the P-loop) identified in this polypeptide, as well as the pharmacologically relevant Cys254. In contrast, the A2-specific cassette does not contain any of these featu ...[more]