Ontology highlight
ABSTRACT:
SUBMITTER: Kondo T
PROVIDER: S-EPMC4175543 | biostudies-other | 2014 Aug
REPOSITORIES: biostudies-other
Stem cell reports 20140626 2
Transplantation of glial-rich neural progenitors has been demonstrated to attenuate motor neuron degeneration and disease progression in rodent models of mutant superoxide dismutase 1 (SOD1)-mediated amyotrophic lateral sclerosis (ALS). However, translation of these results into a clinical setting requires a renewable human cell source. Here, we derived glial-rich neural progenitors from human iPSCs and transplanted them into the lumbar spinal cord of ALS mouse models. The transplanted cells dif ...[more]