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Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice.

ABSTRACT: Transplantation of glial-rich neural progenitors has been demonstrated to attenuate motor neuron degeneration and disease progression in rodent models of mutant superoxide dismutase 1 (SOD1)-mediated amyotrophic lateral sclerosis (ALS). However, translation of these results into a clinical setting requires a renewable human cell source. Here, we derived glial-rich neural progenitors from human iPSCs and transplanted them into the lumbar spinal cord of ALS mouse models. The transplanted cells differentiated into astrocytes, and the treated mouse group showed prolonged lifespan. Our data suggest a potential therapeutic mechanism via activation of AKT signal. The results demonstrated the efficacy of cell therapy for ALS by the use of human iPSCs as cell source.

SUBMITTER: Kondo T

PROVIDER: S-EPMC4175543 | biostudies-other | 2014 Aug

REPOSITORIES: biostudies-other

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Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice.

Kondo Takayuki T Funayama Misato M Tsukita Kayoko K Hotta Akitsu A Yasuda Akimasa A Nori Satoshi S Kaneko Shinjiro S Nakamura Masaya M Takahashi Ryosuke R Okano Hideyuki H Yamanaka Shinya S Inoue Haruhisa H

Stem cell reports 20140626 2

Transplantation of glial-rich neural progenitors has been demonstrated to attenuate motor neuron degeneration and disease progression in rodent models of mutant superoxide dismutase 1 (SOD1)-mediated amyotrophic lateral sclerosis (ALS). However, translation of these results into a clinical setting requires a renewable human cell source. Here, we derived glial-rich neural progenitors from human iPSCs and transplanted them into the lumbar spinal cord of ALS mouse models. The transplanted cells dif ...[more]

PMID: 25254338

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