Ontology highlight
ABSTRACT:
SUBMITTER: Benedetti F
PROVIDER: S-EPMC4176356 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Nucleic acids research 20140814 16
Using Brownian dynamics simulations, we investigate here one of possible roles of supercoiling within topological domains constituting interphase chromosomes of higher eukaryotes. We analysed how supercoiling affects the interaction between enhancers and promoters that are located in the same or in neighbouring topological domains. We show here that enhancer-promoter affinity and supercoiling act synergistically in increasing the fraction of time during which enhancer and promoter stay in contac ...[more]