Ontology highlight
ABSTRACT:
SUBMITTER: Demircioglu FE
PROVIDER: S-EPMC4183299 | biostudies-other | 2014 Sep
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20140904 38
Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) and Sec1/Munc18 (SM) proteins constitute the core of an ancient vesicle fusion machine that diversified into distinct sets that now function in different trafficking steps in eukaryotic cells. Deciphering their precise mode of action has proved challenging. SM proteins are thought to act primarily through one type of SNARE protein, the syntaxins. Despite high structural similarity, however, contrasting binding modes ha ...[more]