Dataset Information

RNA epigenetics.

ABSTRACT: Mammalian messenger RNA (mRNA) and long noncoding RNA (lncRNA) contain tens of thousands of posttranscriptional chemical modifications. Among these, the N(6)-methyl-adenosine (m(6)A) modification is the most abundant and can be removed by specific mammalian enzymes. m(6)A modification is recognized by families of RNA binding proteins that affect many aspects of mRNA function. mRNA/lncRNA modification represents another layer of epigenetic regulation of gene expression, analogous to DNA methylation and histone modification.

SUBMITTER: Liu N

PROVIDER: S-EPMC4190089 | biostudies-other | 2015 Jan

REPOSITORIES: biostudies-other

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Publications

RNA epigenetics.

Liu Nian N Pan Tao T

Translational research : the journal of laboratory and clinical medicine 20140408 1

Mammalian messenger RNA (mRNA) and long noncoding RNA (lncRNA) contain tens of thousands of posttranscriptional chemical modifications. Among these, the N(6)-methyl-adenosine (m(6)A) modification is the most abundant and can be removed by specific mammalian enzymes. m(6)A modification is recognized by families of RNA binding proteins that affect many aspects of mRNA function. mRNA/lncRNA modification represents another layer of epigenetic regulation of gene expression, analogous to DNA methylati ...[more]

PMID: 24768686

Dataset Information

RNA epigenetics.

Publications

RNA epigenetics.

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