Translational control in germline stem cell development.
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ABSTRACT: Stem cells give rise to tissues and organs during development and maintain their integrity during adulthood. They have the potential to self-renew or differentiate at each division. To ensure proper organ growth and homeostasis, self-renewal versus differentiation decisions need to be tightly controlled. Systematic genetic studies in Drosophila melanogaster are revealing extensive regulatory networks that control the switch between stem cell self-renewal and differentiation in the germline. These networks, which are based primarily on mutual translational repression, act via interlocked feedback loops to provide robustness to this important fate decision.
SUBMITTER: Slaidina M
PROVIDER: S-EPMC4195835 | biostudies-other | 2014 Oct
REPOSITORIES: biostudies-other
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