Ontology highlight
ABSTRACT:
SUBMITTER: Jang SM
PROVIDER: S-EPMC4197879 | biostudies-other | 2014 Jun
REPOSITORIES: biostudies-other
Jang Suk Min SM Azebi Saliha S Soubigou Guillaume G Muchardt Christian C
EMBO reports 20140512 6
Heterochromatin protein 1 (HP1) proteins are chromatin-bound transcriptional regulators. While their chromodomain binds histone H3 methylated on lysine 9, their chromoshadow domain associates with the H3 histone fold in a region involved in chromatin remodeling. Here, we show that phosphorylation at histone H3 threonine 45 and serine 57 within this latter region differentially affects binding of the three mammalian HP1 isoforms HP1α, HP1β and HP1γ. Both phosphorylation events are dependent on th ...[more]