Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC4197882 | biostudies-other | 2014 Jun
REPOSITORIES: biostudies-other
EMBO reports 20140407 6
While molecular regulation of insulin granule exocytosis is relatively well understood, insulin granule biogenesis and maturation and its influence on glucose homeostasis are relatively unclear. Here, we identify a novel protein highly expressed in insulin-secreting cells and name it BIG3 due to its similarity to BIG/GBF of the Arf-GTP exchange factor (GEF) family. BIG3 is predominantly localized to insulin- and clathrin-positive trans-Golgi network (TGN) compartments. BIG3-deficient insulin-sec ...[more]