Ontology highlight
ABSTRACT:
SUBMITTER: Bose A
PROVIDER: S-EPMC419880 | biostudies-other | 2004 Jun
REPOSITORIES: biostudies-other
Bose Avirup A Robida Stacey S Furcinitti Paul S PS Chawla Anil A Fogarty Kevin K Corvera Silvia S Czech Michael P MP
Molecular and cellular biology 20040601 12
Glucose homeostasis is controlled in part by regulation of glucose uptake into muscle and adipose tissue. Intracellular membrane vesicles containing the GLUT4 glucose transporter move towards the cell cortex in response to insulin and then fuse with the plasma membrane. Here we show that the fusion step is retarded by the inhibition of phosphatidylinositol (PI) 3-kinase. Treatment of insulin-stimulated 3T3-L1 adipocytes with the PI 3-kinase inhibitor LY294002 causes the accumulation of GLUT4-con ...[more]