Ontology highlight
ABSTRACT:
SUBMITTER: Blake DJ
PROVIDER: S-EPMC42028 | biostudies-other | 1995 Apr
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19950401 9
The utrophin gene is closely related to the dystrophin gene in both sequence and genomic structure. The Duchenne muscular dystrophy (DMD) locus encodes three 14-kb dystrophin transcripts in addition to several smaller isoforms, one of which, Dp116, is specific to peripheral nerve. We describe here the corresponding 5.5-kb mRNA from the utrophin locus. This transcript, designated G-utrophin, is of particular interest because it is specifically expressed in the adult mouse brain and appears to be ...[more]