Ontology highlight
ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC4204797 | biostudies-other | 2012 Jan
REPOSITORIES: biostudies-other
Zhou Jiangbing J Patel Toral R TR Fu Michael M Bertram James P JP Saltzman W Mark WM
Biomaterials 20111019 2
Therapies based on RNA interference, using agents such as siRNA, are limited by the absence of safe, efficient vehicles for targeted delivery in vivo. The barriers to siRNA delivery are well known and can be individually overcome by addition of functional modules, such as conjugation of moieties for cell penetration or targeting. But, so far, it has been impossible to engineer multiple modules into a single unit. Here, we describe the synthesis of degradable nanoparticles that carry eight synerg ...[more]