CSF1 overexpression has pleiotropic effects on microglia in vivo.
Ontology highlight
ABSTRACT:
SUBMITTER: De I
PROVIDER: S-EPMC4205273 | biostudies-other | 2014 Dec
REPOSITORIES: biostudies-other
Publications
CSF1 overexpression has pleiotropic effects on microglia in vivo.
De Ishani I Nikodemova Maria M Steffen Megan D MD Sokn Emily E Maklakova Vilena I VI Watters Jyoti J JJ Collier Lara S LS
Glia 20140705 12
Macrophage colony stimulating factor (CSF1) is a cytokine that is upregulated in several diseases of the central nervous system (CNS). To examine the effects of CSF1 overexpression on microglia, transgenic mice that overexpress CSF1 in the glial fibrillary acidic protein (GFAP) compartment were generated. CSF1 overexpressing mice have increased microglial proliferation and increased microglial numbers compared with controls. Treatment with PLX3397, a small molecule inhibitor of the CSF1 receptor ...[more]
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