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TargetCompare: A web interface to compare simultaneous miRNAs targets.

ABSTRACT: MicroRNAs (miRNAs) are small non-coding nucleotide sequences between 17 and 25 nucleotides in length that primarily function in the regulation of gene expression. A since miRNA has thousand of predict targets in a complex, regulatory cell signaling network. Therefore, it is of interest to study multiple target genes simultaneously. Hence, we describe a web tool (developed using Java programming language and MySQL database server) to analyse multiple targets of pre-selected miRNAs. We cross validated the tool in eight most highly expressed miRNAs in the antrum region of stomach. This helped to identify 43 potential genes that are target of at least six of the referred miRNAs. The developed tool aims to reduce the randomness and increase the chance of selecting strong candidate target genes and miRNAs responsible for playing important roles in the studied tissue.http://lghm.ufpa.br/targetcompare.

SUBMITTER: Moreira FC

PROVIDER: S-EPMC4209372 | biostudies-other | 2014

REPOSITORIES: biostudies-other

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TargetCompare: A web interface to compare simultaneous miRNAs targets.

Moreira Fabiano Cordeiro FC Dustan Bruno B Hamoy Igor G IG Ribeiro-Dos-Santos André M AM Dos Santos Andrea Ribeiro AR

Bioinformation 20140930 9

<h4>Unlabelled</h4>MicroRNAs (miRNAs) are small non-coding nucleotide sequences between 17 and 25 nucleotides in length that primarily function in the regulation of gene expression. A since miRNA has thousand of predict targets in a complex, regulatory cell signaling network. Therefore, it is of interest to study multiple target genes simultaneously. Hence, we describe a web tool (developed using Java programming language and MySQL database server) to analyse multiple targets of pre-selected miR ...[more]

PMID: 25352731

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