Ontology highlight
ABSTRACT:
SUBMITTER: Picco G
PROVIDER: S-EPMC4209794 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Picco Gianfranco G Beatson Richard R Taylor-Papadimitriou Joyce J Burchell Joy M JM
European journal of immunology 20140417 7
DCs are the most potent APCs and are the focus of many immunotherapeutic approaches for the treatment of cancer, although most of these approaches require the ex vivo generation and pulsing of DCs. We have targeted a subset of DCs in vivo using an Ab to DNGR-1, a C-type lectin dedicated to the cross-presentation of Ag expressed by subsets of DCs. HLA-A2 epitopes from the tumour-associated Ag, MUC1, were coupled to the anti-DNGR-1 Ab, and their efficacy in generating a Th1-cell response and inhib ...[more]