Ontology highlight
ABSTRACT:
SUBMITTER: Kim SH
PROVIDER: S-EPMC4210115 | biostudies-other | 2014 Oct
REPOSITORIES: biostudies-other
Journal of the American Chemical Society 20141007 42
The active, stretched conformation of the RecA filament bound to single-stranded DNA is required for homologous recombination. During this process, the RecA filament mediates the homology search and base pair exchange with a complementary sequence. Subsequently, the RecA filament dissociates from DNA upon reaction completion. ATP binding and hydrolysis is critical throughout these processes. Little is known about the timescale, order of conversion between different cofactor bound forms during AT ...[more]