Ontology highlight
ABSTRACT:
SUBMITTER: Ruat M
PROVIDER: S-EPMC42125 | biostudies-other | 1995 Apr
REPOSITORIES: biostudies-other
Ruat M M Molliver M E ME Snowman A M AM Snyder S H SH
Proceedings of the National Academy of Sciences of the United States of America 19950401 8
We have molecularly cloned a calcium sensing receptor (CaSR) from a rat striatal cDNA library. Rat CaSR displays 92% overall homology to its bovine counterpart with seven putative transmembrane domains characteristic of the superfamily of guanine nucleotide-binding proteins and significant homology with the metabotropic glutamate receptors. Northern blot analysis reveals two transcripts in thyroid, kidney, lung, ileum, and pituitary. In brain highest regional expression of the RNA occurs in the ...[more]