Ontology highlight
ABSTRACT:
SUBMITTER: Kim EJ
PROVIDER: S-EPMC4215860 | biostudies-other | 2014 Jun
REPOSITORIES: biostudies-other
Bioconjugate chemistry 20140602 6
The dynamic glycosylation of serine/threonine residues on nucleocytoplasmic proteins with a single N-acetylglucosamine (O-GlcNAcylation) is critical for many important cellular processes. Cellular O-GlcNAc levels are highly regulated by two enzymes: O-GlcNAc transferase (OGT) is responsible for GlcNAc addition and O-GlcNAcase (OGA) is responsible for removal of the sugar. The lack of a rapid and simple method for monitoring OGT activity has impeded the efficient discovery of potent OGT inhibitor ...[more]