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Total synthesis of the proposed structure of astakolactin.

ABSTRACT: The first total synthesis of the proposed structure of astakolactin, a sesterterpene metabolite isolated from the marine sponge Cacospongia scalaris, has been achieved, mainly featuring Johnson-Claisen rearrangement, asymmetric Mukaiyama aldol reaction and MNBA-mediated lactonization.

SUBMITTER: Tonoi T

PROVIDER: S-EPMC4222296 | biostudies-other | 2014

REPOSITORIES: biostudies-other

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Total synthesis of the proposed structure of astakolactin.

Tonoi Takayuki T Mameda Keisuke K Fujishiro Moe M Yoshinaga Yutaka Y Shiina Isamu I

Beilstein journal of organic chemistry 20141017

The first total synthesis of the proposed structure of astakolactin, a sesterterpene metabolite isolated from the marine sponge Cacospongia scalaris, has been achieved, mainly featuring Johnson-Claisen rearrangement, asymmetric Mukaiyama aldol reaction and MNBA-mediated lactonization. ...[more]

PMID: 25383112

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