Ontology highlight
ABSTRACT:
SUBMITTER: Gopinath S
PROVIDER: S-EPMC4226084 | biostudies-other | 2014 Nov
REPOSITORIES: biostudies-other
Gopinath Smita S Lichtman Joshua S JS Bouley Donna M DM Elias Joshua E JE Monack Denise M DM
Proceedings of the National Academy of Sciences of the United States of America 20141020 44
Natural populations show striking heterogeneity in their ability to transmit disease. For example, a minority of infected individuals known as superspreaders carries out the majority of pathogen transmission events. In a mouse model of Salmonella infection, a subset of infected hosts becomes superspreaders, shedding high levels of bacteria (>10(8) cfu per g of feces) but remain asymptomatic with a dampened systemic immune state. Here we show that superspreader hosts remain asymptomatic when they ...[more]