Ontology highlight
ABSTRACT:
SUBMITTER: Ramirez LA
PROVIDER: S-EPMC4226794 | biostudies-other | 2014 Dec
REPOSITORIES: biostudies-other
Journal of leukocyte biology 20140825 6
HIV-1-infected subjects, despite control of viral replication with ART, have an altered immune cytokine/chemokine milieu. Changes in systemic cytokines and chemokines can alter immune responses. IP-10, in particular, has been associated with pathogenesis in a number of conditions, and we found that IP-10 is increased in serum in subjects who are HIV-1 infected and on stable ART compared with HIV-1-uninfected individuals. In a series of in vitro studies, we found that PBMCs exposed to IP-10 showe ...[more]