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Optimal seasonal timing of oral azithromycin for malaria.

ABSTRACT: Mass administration of azithromycin for trachoma has been shown to reduce malarial parasitemia. However, the optimal seasonal timing of such distributions for antimalarial benefit has not been established. We performed numerical analyses on a seasonally forced epidemic model (of Ross-Macdonald type) with periodic impulsive annual mass treatment to address this question. We conclude that when azithromycin-based trachoma elimination programs occur in regions of seasonal malaria transmission, such as Niger, the optimal seasonal timing of mass drug administration (MDA) may not occur during the season of maximum transmission.

SUBMITTER: Gao D

PROVIDER: S-EPMC4228890 | biostudies-other | 2014 Nov

REPOSITORIES: biostudies-other

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Optimal seasonal timing of oral azithromycin for malaria.

Gao Daozhou D Amza Abdou A Nassirou Baidou B Kadri Boubacar B Sippl-Swezey Nicholas N Liu Fengchen F Ackley Sarah F SF Lietman Thomas M TM Porco Travis C TC

The American journal of tropical medicine and hygiene 20140915 5

Mass administration of azithromycin for trachoma has been shown to reduce malarial parasitemia. However, the optimal seasonal timing of such distributions for antimalarial benefit has not been established. We performed numerical analyses on a seasonally forced epidemic model (of Ross-Macdonald type) with periodic impulsive annual mass treatment to address this question. We conclude that when azithromycin-based trachoma elimination programs occur in regions of seasonal malaria transmission, such ...[more]

PMID: 25223942

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