Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase.
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ABSTRACT:
SUBMITTER: Lukesh JC
PROVIDER: S-EPMC4237591 | biostudies-other | 2014 Nov
REPOSITORIES: biostudies-other
Publications
Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase.
Lukesh John C JC Andersen Kristen A KA Wallin Kelly K KK Raines Ronald T RT
Organic & biomolecular chemistry 20141101 43
Organocatalysts derived from diethylenetriamine effect the rapid isomerization of non-native protein disulfide bonds to native ones. These catalysts contain a pendant hydrophobic moiety to encourage interaction with the non-native state, and two thiol groups with low pKa values that form a disulfide bond with a high E°' value. ...[more]
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