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Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases.

ABSTRACT: Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.

SUBMITTER: Smith AC 

PROVIDER: S-EPMC4241163 | biostudies-other | 2014 Dec

REPOSITORIES: biostudies-other

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Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases.

Smith Alexander C W AC   Kupchik Yonatan M YM   Scofield Michael D MD   Gipson Cassandra D CD   Wiggins Armina A   Thomas Charles A CA   Kalivas Peter W PW  

Nature neuroscience 20141019 12

Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocain  ...[more]