Dataset Information

Integrating PPI datasets with the PPI data from biomedical literature for protein complex detection.

ABSTRACT: BACKGROUND: Protein complexes are important for understanding principles of cellular organization and function. High-throughput experimental techniques have produced a large amount of protein-protein interactions (PPIs), making it possible to predict protein complexes from protein-protein interaction networks. On the other hand, the rapidly growing biomedical literature provides a significantly large and readily available source of interaction data, which can be integrated into the protein network for better complex detection performance. METHODS: We present an approach of integrating PPI datasets with the PPI data from biomedical literature for protein complex detection. The approach applies a sophisticated natural language processing system, PPIExtractor, to extract PPI data from biomedical literature. These data are then integrated into the PPI datasets for complex detection. RESULTS: The experimental results of the state-of-the-art complex detection method, ClusterONE, on five yeast PPI datasets verify our method's effectiveness: compared with the original PPI datasets, the average improvements of 3.976 and 5.416 percentage units in the maximum matching ratio (MMR) are achieved on the new networks using the MIPS and SGD gold standards, respectively. In addition, our approach also proves to be effective for three other complex detection algorithms proposed in recent years, i.e. CMC, COACH and RRW. CONCLUSIONS: The rapidly growing biomedical literature provides a significantly large, readily available and relatively accurate source of interaction data, which can be integrated into the protein network for better protein complex detection performance.

SUBMITTER: Yang Z

PROVIDER: S-EPMC4243118 | biostudies-other | 2014

REPOSITORIES: biostudies-other

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Integrating PPI datasets with the PPI data from biomedical literature for protein complex detection.

Yang Zhi Z Yu Feng F Lin Hong H Wang Jian J

BMC medical genomics 20141022

<h4>Background</h4>Protein complexes are important for understanding principles of cellular organization and function. High-throughput experimental techniques have produced a large amount of protein-protein interactions (PPIs), making it possible to predict protein complexes from protein-protein interaction networks. On the other hand, the rapidly growing biomedical literature provides a significantly large and readily available source of interaction data, which can be integrated into the protei ...[more]

PMID: 25350598

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Project description:BackgroundIdentification of protein complexes and functional modules from protein-protein interaction (PPI) networks is crucial to understanding the principles of cellular organization and predicting protein functions. In the past few years, many computational methods have been proposed. However, most of them considered the PPI networks as static graphs and overlooked the dynamics inherent within these networks. Moreover, few of them can distinguish between protein complexes and functional modules.ResultsIn this paper, a new framework is proposed to distinguish between protein complexes and functional modules by integrating gene expression data into protein-protein interaction (PPI) data. A series of time-sequenced subnetworks (TSNs) is constructed according to the time that the interactions were activated. The algorithm TSN-PCD was then developed to identify protein complexes from these TSNs. As protein complexes are significantly related to functional modules, a new algorithm DFM-CIN is proposed to discover functional modules based on the identified complexes. The experimental results show that the combination of temporal gene expression data with PPI data contributes to identifying protein complexes more precisely. A quantitative comparison based on f-measure reveals that our algorithm TSN-PCD outperforms the other previous protein complex discovery algorithms. Furthermore, we evaluate the identified functional modules by using "Biological Process" annotated in GO (Gene Ontology). The validation shows that the identified functional modules are statistically significant in terms of "Biological Process". More importantly, the relationship between protein complexes and functional modules are studied.ConclusionsThe proposed framework based on the integration of PPI data and gene expression data makes it possible to identify protein complexes and functional modules more effectively. Moveover, the proposed new framework and algorithms can distinguish between protein complexes and functional modules. Our findings suggest that functional modules are closely related to protein complexes and a functional module may consist of one or multiple protein complexes. The program is available at http://netlab.csu.edu.cn/bioinfomatics/limin/DFM-CIN/index.html.

Dataset Information

Integrating PPI datasets with the PPI data from biomedical literature for protein complex detection.

Publications

Integrating PPI datasets with the PPI data from biomedical literature for protein complex detection.

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