Ontology highlight
ABSTRACT:
SUBMITTER: Vician L
PROVIDER: S-EPMC42444 | biostudies-other | 1995 Mar
REPOSITORIES: biostudies-other
Vician L L Lim I K IK Ferguson G G Tocco G G Baudry M M Herschman H R HR
Proceedings of the National Academy of Sciences of the United States of America 19950301 6
Subtractive library construction and differential screening were used to identify a cDNA for a cell type-specific immediate early gene induced in rat PC12 pheochromocytoma cells. Sequencing identified the protein product of this gene as rat synaptotagmin IV (SytIV). Synaptotagmins are synaptic vesicle proteins thought to play a role in depolarization-induced, calcium-mediated exocytosis and neurotransmitter release. SytIV mRNA accumulation is transiently induced in PC12 cells by potassium depola ...[more]