Ontology highlight
ABSTRACT:
SUBMITTER: Tebbutt SJ
PROVIDER: S-EPMC42470 | biostudies-other | 1995 Mar
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19950301 6
There is a need for a large-animal model to investigate the etiology and biology of cystic fibrosis (CF) lung disease and to study potential therapies. The development and electrophysiology of the sheep airway have been shown to exhibit close functional parallels with the human airway, particularly with respect to the respiratory epithelium. We have cloned and sequenced the ovine cystic fibrosis transmembrane conductance regulator (CFTR) cDNA. It shows a high degree of conservation at the DNA co ...[more]