Ontology highlight
ABSTRACT:
SUBMITTER: Anthony K
PROVIDER: S-EPMC4248450 | biostudies-other | 2014 Nov
REPOSITORIES: biostudies-other
Anthony Karen K Arechavala-Gomeza Virginia V Taylor Laura E LE Vulin Adeline A Kaminoh Yuuki Y Torelli Silvia S Feng Lucy L Janghra Narinder N Bonne Gisèle G Beuvin Maud M Barresi Rita R Henderson Matt M Laval Steven S Lourbakos Afrodite A Campion Giles G Straub Volker V Voit Thomas T Sewry Caroline A CA Morgan Jennifer E JE Flanigan Kevin M KM Muntoni Francesco F
Neurology 20141029 22
<h4>Objective</h4>We formed a multi-institution collaboration in order to compare dystrophin quantification methods, reach a consensus on the most reliable method, and report its biological significance in the context of clinical trials.<h4>Methods</h4>Five laboratories with expertise in dystrophin quantification performed a data-driven comparative analysis of a single reference set of normal and dystrophinopathy muscle biopsies using quantitative immunohistochemistry and Western blotting. We de ...[more]