Ontology highlight
ABSTRACT:
SUBMITTER: Esmaeilzadeh Gharehdaghi E
PROVIDER: S-EPMC4250949 | biostudies-other | 2014 Dec
REPOSITORIES: biostudies-other
Esmaeilzadeh Gharehdaghi Elina E Amani Amir A Khoshayand Mohammad Reza MR Banan Mehdi M Esmaeilzadeh Gharehdaghi Elika E Amini Mohammad Ali MA Faramarzi Mohammad Ali MA
Nucleic acid therapeutics 20141201 6
Chitosan nanoparticles were prepared using ultrasonication methodology at specific amplitudes and times of sonication. Subsequently, small interfering RNA (siRNA) was added to the solution at predetermined values of nitrogen to phosphorous ratio (N/P), and stirring time. Employing response surfaces generated from a statistical model, the effect of sonication time and amplitude, stirring time, and N/P ratio was studied on the particle size, polydispersity, and loading efficiency of prepared siRNA ...[more]