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Chimera: a Bioconductor package for secondary analysis of fusion products.

ABSTRACT: SUMMARY: Chimera is a Bioconductor package that organizes, annotates, analyses and validates fusions reported by different fusion detection tools; current implementation can deal with output from bellerophontes, chimeraScan, deFuse, fusionCatcher, FusionFinder, FusionHunter, FusionMap, mapSplice, Rsubread, tophat-fusion and STAR. The core of Chimera is a fusion data structure that can store fusion events detected with any of the aforementioned tools. Fusions are then easily manipulated with standard R functions or through the set of functionalities specifically developed in Chimera with the aim of supporting the user in managing fusions and discriminating false-positive results.

SUBMITTER: Beccuti M

PROVIDER: S-EPMC4253834 | biostudies-other | 2014 Dec

REPOSITORIES: biostudies-other

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Chimera: a Bioconductor package for secondary analysis of fusion products.

Beccuti Marco M Carrara Matteo M Cordero Francesca F Lazzarato Fulvio F Donatelli Susanna S Nadalin Francesca F Policriti Alberto A Calogero Raffaele A RA

Bioinformatics (Oxford, England) 20141006 24

<h4>Summary</h4>Chimera is a Bioconductor package that organizes, annotates, analyses and validates fusions reported by different fusion detection tools; current implementation can deal with output from bellerophontes, chimeraScan, deFuse, fusionCatcher, FusionFinder, FusionHunter, FusionMap, mapSplice, Rsubread, tophat-fusion and STAR. The core of Chimera is a fusion data structure that can store fusion events detected with any of the aforementioned tools. Fusions are then easily manipulated wi ...[more]

PMID: 25286921

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