Osteoarthritis joint pain: the cytokine connection.
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ABSTRACT:
SUBMITTER: Miller RE
PROVIDER: S-EPMC4254338 | biostudies-other | 2014 Dec
REPOSITORIES: biostudies-other
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Osteoarthritis joint pain: the cytokine connection.
Miller Rachel E RE Miller Richard J RJ Malfait Anne-Marie AM
Cytokine 20140724 2
Osteoarthritis is a chronic and painful disease of synovial joints. Chondrocytes, synovial cells and other cells in the joint can express and respond to cytokines and chemokines, and all of these molecules can also be detected in synovial fluid of patients with osteoarthritis. The presence of inflammatory cytokines in the osteoarthritic joint raises the question whether they may directly participate in pain generation by acting on innervating joint nociceptors. Here, we first provide a systemati ...[more]
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