Ontology highlight
ABSTRACT:
SUBMITTER: Riching KM
PROVIDER: S-EPMC4255204 | biostudies-other | 2014 Dec
REPOSITORIES: biostudies-other
Riching Kristin M KM Cox Benjamin L BL Salick Max R MR Pehlke Carolyn C Riching Andrew S AS Ponik Susan M SM Bass Benjamin R BR Crone Wendy C WC Jiang Yi Y Weaver Alissa M AM Eliceiri Kevin W KW Keely Patricia J PJ
Biophysical journal 20141202 11
Patients with mammographically dense breast tissue have a greatly increased risk of developing breast cancer. Dense breast tissue contains more stromal collagen, which contributes to increased matrix stiffness and alters normal cellular responses. Stromal collagen within and surrounding mammary tumors is frequently aligned and reoriented perpendicular to the tumor boundary. We have shown that aligned collagen predicts poor outcome in breast cancer patients, and postulate this is because it facil ...[more]