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Targeting the Neuropeptide Y System in Stress-related Psychiatric Disorders.


ABSTRACT: Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many negative physical and psychological outcomes. Stressors can precipitate the onset of psychiatric diseases, or exacerbate pre-existing disorders including various anxiety and mood disorders. As stressors can negatively impact human psychiatric health, it is essential to identify neurochemicals that may confer protection from the negative sequelae of repeated or extreme stress exposure. Elucidating the neurobiological underpinnings of stress resilience will enhance our ability to promote resilience to, or recovery from, stress-related psychiatric disease. Herein, we will review the evidence for neuropeptide Y as an endogenous mediator of resilience and its potential relevance for the treatment of stress-related psychiatric diseases.

SUBMITTER: Enman NM 

PROVIDER: S-EPMC4260418 | biostudies-other | 2015 Jan

REPOSITORIES: biostudies-other

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Targeting the Neuropeptide Y System in Stress-related Psychiatric Disorders.

Enman Nicole M NM   Sabban Esther L EL   McGonigle Paul P   Van Bockstaele Elisabeth J EJ  

Neurobiology of stress 20150101


Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many negative physical and psychological outcomes. Stressors can precipitate the onset of psychiatric diseases, or exacerbate pre-existing disorders including various anxiety and mood disorders. As stressors can negatively impact human psychiatric health, it is essential to identify neurochemicals that may confer protection from the negative sequelae of repeated or extreme stress exposure. Elucidating the neurob  ...[more]

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