Ontology highlight
ABSTRACT:
SUBMITTER: Dube JJ
PROVIDER: S-EPMC4269675 | biostudies-other | 2014 Dec
REPOSITORIES: biostudies-other
Dubé John J JJ Coen Paul M PM DiStefano Giovanna G Chacon Alexander C AC Helbling Nicole L NL Desimone Marisa E ME Stafanovic-Racic Maja M Hames Kazanna C KC Despines Alex A AA Toledo Frederico G S FG Goodpaster Bret H BH
American journal of physiology. Endocrinology and metabolism 20141028 12
We hypothesized that acute lipid-induced insulin resistance would be attenuated in high-oxidative muscle of lean trained (LT) endurance athletes due to their enhanced metabolic flexibility and mitochondrial capacity. Lean sedentary (LS), obese sedentary (OS), and LT participants completed two hyperinsulinemic euglycemic clamp studies with and without (glycerol control) the coinfusion of Intralipid. Metabolic flexibility was measured by indirect calorimetry as the oxidation of fatty acids and glu ...[more]