Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Isidoro R
PROVIDER: S-EPMC4269894 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Pérez-Isidoro Rosendo R Sierra-Valdez F J FJ Ruiz-Suárez J C JC
Scientific reports 20141218
Hundreds of substances possess anesthetic action. However, despite decades of research and tests, a golden rule is required to reconcile the diverse hypothesis behind anesthesia. What makes an anesthetic to be local or general in the first place? The specific targets on proteins, the solubility in lipids, the diffusivity, potency, action time? Here we show that there could be a new player equally or even more important to disentangle the riddle: the protonation rate. Indeed, such rate modulates ...[more]