CD18 (beta 2 leukocyte integrin) promoter requires PU.1 transcription factor for myeloid activity.
Ontology highlight
ABSTRACT:
SUBMITTER: Rosmarin AG
PROVIDER: S-EPMC42708 | biostudies-other | 1995 Jan
REPOSITORIES: biostudies-other
Publications
CD18 (beta 2 leukocyte integrin) promoter requires PU.1 transcription factor for myeloid activity.
Rosmarin A G AG Caprio D D Levy R R Simkevich C C
Proceedings of the National Academy of Sciences of the United States of America 19950101 3
Normal cellular differentiation is linked to tightly regulated gene transcription. However, the DNA elements and trans-acting factors that regulate transcription in myeloid cells are poorly defined. CD18, the beta chain of the leukocyte integrins, is transcriptionally regulated during myeloid differentiation. The CD18 promoter is active after transfection into myeloid cells. We demonstrate that a region of the CD18 promoter that contains two binding sites for the PU.1 transcription factor is req ...[more]
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