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Blunted striatal responses to favorite-food cues in smokers.

ABSTRACT: Although tobacco-smoking is associated with relatively leaner body mass and smoking cessation with weight gain, the brain mechanisms underlying these relationships are not well understood. Smokers compared to non-smokers have shown diminished neural responses to non-tobacco rewarding stimuli (e.g., monetary rewards), but brain responses to favorite-food cues have not been investigated relative to smoking status. We hypothesized that smokers would exhibit diminished neural responses compared to non-smokers in response to favorite-food cues in motivation-reward and emotion-regulating regions of the brain.Twenty-three smokers and 23 non-smokers matched based on body mass index (BMI), age, and gender listened to personalized favorite-food cue, stress, and neutral-relaxing audiotapes during fMRI.During favorite-food cue exposure, smokers versus non-smokers exhibited diminished activations in the caudate, putamen, insula, and thalamus. Neural responses during stress and neutral-relaxing conditions were similar across groups. Subjective food-craving ratings were similar across groups.The relatively diminished neural responses to favorite-food cues in smokers may contribute to lower BMI.

SUBMITTER: Jastreboff AM

PROVIDER: S-EPMC4272899 | biostudies-other | 2015 Jan

REPOSITORIES: biostudies-other

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Blunted striatal responses to favorite-food cues in smokers.

Jastreboff Ania M AM Sinha Rajita R Lacadie Cheryl M CM Balodis Iris M IM Sherwin Robert R Potenza Marc N MN

Drug and alcohol dependence 20140918

<h4>Background</h4>Although tobacco-smoking is associated with relatively leaner body mass and smoking cessation with weight gain, the brain mechanisms underlying these relationships are not well understood. Smokers compared to non-smokers have shown diminished neural responses to non-tobacco rewarding stimuli (e.g., monetary rewards), but brain responses to favorite-food cues have not been investigated relative to smoking status. We hypothesized that smokers would exhibit diminished neural resp ...[more]

PMID: 25444233

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Dataset Information

Blunted striatal responses to favorite-food cues in smokers.

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Blunted striatal responses to favorite-food cues in smokers.

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