Palladium-catalyzed 2,5-diheteroarylation of 2,5-dibromothiophene derivatives.

ABSTRACT: Conditions allowing the one pot 2,5-diheteroarylation of 2,5-dibromothiophene derivatives in the presence of palladium catalysts are reported. Using KOAc as the base, DMA as the solvent and only 0.5-2 mol % palladium catalysts, the target 2,5-diheteroarylated thiophenes were obtained in moderate to good yields and with a wide variety of heteroarenes such as thiazoles, thiophenes, furans, pyrroles, pyrazoles or isoxazoles. Moreover, sequential heteroarylation reactions allow the access to 2,5-diheteroarylated thiophenes bearing two different heteroaryl units.

SUBMITTER: Belkessam F 

PROVIDER: S-EPMC4273267 | biostudies-other | 2014

REPOSITORIES: biostudies-other