Ontology highlight
ABSTRACT:
SUBMITTER: Cosgrove KP
PROVIDER: S-EPMC4273348 | biostudies-other | 2014 Dec
REPOSITORIES: biostudies-other
Cosgrove Kelly P KP McKay Reese R Esterlis Irina I Kloczynski Tracy T Perkins Evgenia E Bois Frederic F Pittman Brian B Lancaster Jack J Glahn David C DC O'Malley Stephanie S Carson Richard E RE Krystal John H JH
Proceedings of the National Academy of Sciences of the United States of America 20141201 50
Understanding the effects of tobacco smoking on neuroadaptations in GABAA receptor levels over alcohol withdrawal will provide critical insights for the treatment of comorbid alcohol and nicotine dependence. We conducted parallel studies in human subjects and nonhuman primates to investigate the differential effects of tobacco smoking and nicotine on changes in GABAA receptor availability during acute and prolonged alcohol withdrawal. We report that alcohol withdrawal with or without concurrent ...[more]