Unknown

Dataset Information

0

Avian cellular homolog of the qin oncogene.


ABSTRACT: We have isolated chicken cDNA clones of the c-qin gene, the cellular counterpart of the v-qin (Chinese for "avian") oncogene of avian sarcoma virus 31. There are several differences between the cellular and the viral qin sequences: (i) two nonconservative amino acid substitutions in the Qin coding region; (ii) a truncation in the carboxyl terminus of the viral protein due to a premature stop codon; (iii) a partial Gag sequence fused to the amino terminus of viral Qin; and (iv) eight cell-coded amino acids which link the cellular Qin coding domain to the viral Gag domain. We have also characterized the expression pattern of c-qin in chicken embryos by in situ hybridization and by Northern blot analysis. c-qin is abundantly expressed in the developing brain, and this expression is restricted to the telencephalon of early embryos.

SUBMITTER: Chang HW 

PROVIDER: S-EPMC42757 | biostudies-other | 1995 Jan

REPOSITORIES: biostudies-other

altmetric image

Publications

Avian cellular homolog of the qin oncogene.

Chang H W HW   Li J J   Kretzschmar D D   Vogt P K PK  

Proceedings of the National Academy of Sciences of the United States of America 19950101 2


We have isolated chicken cDNA clones of the c-qin gene, the cellular counterpart of the v-qin (Chinese for "avian") oncogene of avian sarcoma virus 31. There are several differences between the cellular and the viral qin sequences: (i) two nonconservative amino acid substitutions in the Qin coding region; (ii) a truncation in the carboxyl terminus of the viral protein due to a premature stop codon; (iii) a partial Gag sequence fused to the amino terminus of viral Qin; and (iv) eight cell-coded a  ...[more]

Similar Datasets

| S-EPMC3041169 | biostudies-literature
2022-06-22 | GSE148630 | GEO
| S-EPMC5269692 | biostudies-literature
| S-EPMC26247 | biostudies-literature
| S-EPMC2832214 | biostudies-literature
| S-EPMC3867201 | biostudies-literature
| S-EPMC4061398 | biostudies-literature
| S-EPMC6796977 | biostudies-literature
| S-EPMC5955849 | biostudies-literature
| S-EPMC7270000 | biostudies-literature