Ontology highlight
ABSTRACT:
SUBMITTER: Kanada M
PROVIDER: S-EPMC4277486 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Kanada Masamitsu M Zhang Jinyan J Yan Libo L Sakurai Takashi T Terakawa Susumu S
PeerJ 20141223
The extravasation of cancer cells, a key step for distant metastasis, is thought to be initiated by disruption of the endothelial barrier by malignant cancer cells. An endothelial covering-type extravasation of cancer cells in addition to conventional cancer cell invasion-type extravasation was dynamically visualized in a zebrafish hematogenous metastasis model. The inhibition of VEGF-signaling impaired the invasion-type extravasation via inhibition of cancer cell polarization and motility. Para ...[more]