Influence analysis in quantitative trait loci detection.
Ontology highlight
ABSTRACT:
SUBMITTER: Dou X
PROVIDER: S-EPMC4282084 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Publications
Influence analysis in quantitative trait loci detection.
Dou Xiaoling X Kuriki Satoshi S Maeno Akiteru A Takada Toyoyuki T Shiroishi Toshihiko T
Biometrical journal. Biometrische Zeitschrift 20140417 4
This paper presents systematic methods for the detection of influential individuals that affect the log odds (LOD) score curve. We derive general formulas of influence functions for profile likelihoods and introduce them into two standard quantitative trait locus detection methods-the interval mapping method and single marker analysis. Besides influence analysis on specific LOD scores, we also develop influence analysis methods on the shape of the LOD score curves. A simulation-based method is p ...[more]
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