Ontology highlight
ABSTRACT:
SUBMITTER: Rocha C
PROVIDER: S-EPMC4282510 | biostudies-other | 2014 Oct
REPOSITORIES: biostudies-other
The EMBO journal 20140901 19
TTLL3 and TTLL8 are tubulin glycine ligases catalyzing posttranslational glycylation of microtubules. We show here for the first time that these enzymes are required for robust formation of primary cilia. We further discover the existence of primary cilia in colon and demonstrate that TTLL3 is the only glycylase in this organ. As a consequence, colon epithelium shows a reduced number of primary cilia accompanied by an increased rate of cell division in TTLL3-knockout mice. Strikingly, higher pro ...[more]