A cytolysin encoded by Salmonella is required for survival within macrophages.
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ABSTRACT:
SUBMITTER: Libby SJ
PROVIDER: S-EPMC42974 | biostudies-other | 1994 Jan
REPOSITORIES: biostudies-other
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A cytolysin encoded by Salmonella is required for survival within macrophages.
Libby S J SJ Goebel W W Ludwig A A Buchmeier N N Bowe F F Fang F C FC Guiney D G DG Songer J G JG Heffron F F
Proceedings of the National Academy of Sciences of the United States of America 19940101 2
A Salmonella gene encoding a cytolysin has been identified by screening for hemolysis on blood agar. DNA sequence analyses together with genetic mapping in Salmonella suggest that it is unrelated to other toxins or hemolysins. The gene (slyA) is present in every strain of Salmonella examined, in Shigella, and in enteroinvasive Escherichia coli but not in other Enterobacteriaceae. SlyA (salmolysin) purified from a derivative of the original clone has hemolytic and cytolytic activity and has a mol ...[more]
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