Ontology highlight
ABSTRACT:
SUBMITTER: Halevy T
PROVIDER: S-EPMC4297868 | biostudies-other | 2015 Jan
REPOSITORIES: biostudies-other
Halevy Tomer T Czech Christian C Benvenisty Nissim N
Stem cell reports 20141204 1
Fragile X syndrome (FXS) is caused by the absence of the fragile X mental retardation protein (FMRP). We have previously generated FXS-induced pluripotent stem cells (iPSCs) from patients' fibroblasts. In this study, we aimed at unraveling the molecular phenotype of the disease. Our data revealed aberrant regulation of neural differentiation and axon guidance genes in FXS-derived neurons, which are regulated by the RE-1 silencing transcription factor (REST). Moreover, we found REST to be elevate ...[more]