Ontology highlight
ABSTRACT:
SUBMITTER: Piechura JR
PROVIDER: S-EPMC4308431 | biostudies-other | 2015 Feb
REPOSITORIES: biostudies-other
Piechura Joseph R JR Tseng Tzu-Ling TL Hsu Hsin-Fang HF Byrne Rose T RT Windgassen Tricia A TA Chitteni-Pattu Sindhu S Battista John R JR Li Hung-Wen HW Cox Michael M MM
DNA repair 20141209
Among strains of Escherichia coli that have evolved to survive extreme exposure to ionizing radiation, mutations in the recA gene are prominent and contribute substantially to the acquired phenotype. Changes at amino acid residue 276, D276A and D276N, occur repeatedly and in separate evolved populations. RecA D276A and RecA D276N exhibit unique adaptations to an environment that can require the repair of hundreds of double strand breaks. These two RecA protein variants (a) exhibit a faster rate ...[more]