Ontology highlight
ABSTRACT:
SUBMITTER: Vaeth M
PROVIDER: S-EPMC4313840 | biostudies-other | 2015 Jan
REPOSITORIES: biostudies-other
Vaeth Martin M Bäuerlein Carina A CA Pusch Tobias T Findeis Janina J Chopra Martin M Mottok Anja A Rosenwald Andreas A Beilhack Andreas A Berberich-Siebelt Friederike F
Proceedings of the National Academy of Sciences of the United States of America 20150112 4
Graft-versus-host disease (GvHD) is a life-threatening immunological complication after allogenic hematopoietic stem cell transplantation (allo-HCT). The intrinsic graft-versus-leukemia (GvL) effect, however, is the desirable curative benefit. Patients with acute GvHD are treated with cyclosporine A (CsA) or tacrolimus (FK506), which not only often causes severe adverse effects, but also interferes with the anticipated GvL. Both drugs inhibit calcineurin, thus at first suppressing activation of ...[more]