Ontology highlight
ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC4314519 | biostudies-other | 2015 Mar
REPOSITORIES: biostudies-other
Wang Peng P Kouyoumdjian Hovig H Zhu David C DC Huang Xuefei X
Carbohydrate research 20140802
Accumulation of β amyloid (Aβ) in the brain is believed to play a key role in the pathology of Alzheimer's disease. Glycosaminoglycans on surface of neuronal cells can serve as nucleation sites to promote plaque formation on cell surface. To mimic this process, magnetic nanoparticles coated with heparin have been synthesized. The heparin nanoparticles were demonstrated to bind with Aβ through a variety of techniques including enzyme-linked immunosorbent assay, gel electrophoresis, and thioflavin ...[more]